Recognize schisctocytes on a peripheral blood smear and name common causes of this finding
A 30 yo F with no significant PMH presents with fatigue and was found to have a hct of 18% and platelets of 9k. Her coagulation panel was normal, LDH elevated and haptoglobin was low. A peripheral smear below shows:
What does the above image show?
The above peripheral blood smear shows evidence of schistoctyes.
What disorders as also associated with schistocytes?
Schistocytes can be seen in the following disorders:
- Thrombotic microangiopathies (HUS, TTP)
- Prosthetic heart valve, VADs
- HELLP syndrome
- Less commonly, schistocytes can be seen in:
- HSCT or solid organ transplant patients
- Severe hypertension
- Systemic infection